Therapeutics
What physicians prescribe, and what the evidence supports.
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The week in longevity medicine, every Sunday.
Free, delivered by Substack. Unsubscribe any time.RESEARCH
New StudiesWhat was published and what it meansClinical TrialsWhat is enrolling, what is reading outEvidence CheckWhere the data stands on a claimResearch TranslationFrom the lab to the clinicBiology of AgingHallmarks, senescence, epigenetics
Caloric restriction improves a composite aging-biomarker index
By longevitydocs™ editors
Menopause leaves a molecular signature linked to brain aging
By longevitydocs™ editorsCLINICAL PRACTICE
Practice ModelsHow longevity care is structured and deliveredClinical CasesReal patients, real clinical decisionsGuidelines & StandardsConsensus statements and best practiceField ReportsCLDs on what works in their practice
Ferritin below 30 is the new line
By longevitydocs™ editors
Where can I find a longevity doctor?
By David Luu, MDTHERAPEUTICS
Metabolic HealthGLP-1s, insulin, cardiometabolic riskHormones & Midlife CareHRT, testosterone, menopauseSupplements & PeptidesWhat is proven, what is notRegenerative MedicineStem cells, exosomes, PRPSkin & Aesthetic LongevityLongevity dermatology and aesthetics
Tirzepatide earns its first outcomes label
By longevitydocs™ editors
The Lp(a) drug moved the number, not the outcome
By longevitydocs™ editorsDIAGNOSTICS
BiomarkersBlood panels, ApoB, inflammationBiological AgeEpigenetic clocks and how to read themImagingFull-body MRI, CAC scores, DEXAGenomicsPolygenic risk, pharmacogenomicsScreening & PreventionEarly detection and risk reduction
Alzheimer’s blood tests are for symptomatic patients, not screening
By longevitydocs™ editors
Which longevity data is worth acting on?
By David Luu, MDTECHNOLOGY
AI in MedicineClinical tools, decision supportWearables & Remote MonitoringCGMs, rings, continuous dataDevices & At-Home CareHome diagnostics and hardwareDigital Health InfrastructurePlatforms, records, telehealth
Lab-grade breath testing goes self-serve
By longevitydocs™ editors
Your ring now carries your chart
By longevitydocs™ editorsBUSINESS
Clinics & PracticesModels, pricing, operationsCare DeliveryHow providers and health systems offer longevity carePharma & BiotechPipelines, launches, trialsDeals & FundingRaises, M&A, partnerships
System raises $20M to own the peptide supply chain
By longevitydocs™ editors
Bryan Johnson’s Immortals Concierge: from $75k to $1M
By longevitydocs™ editorsPOLICY
Regulation & EnforcementFDA actions, compounding, warningsPayment & ReimbursementCoverage, codes, payersLicensure & StandardsScope of practice, credentialingGlobal PolicyHow other countries regulate longevity care
FDA puts a major GLP-1 compounder on notice
By longevitydocs™ editors
$16.4 trillion: the economic case for prevention
By longevitydocs™ editorsVOICES
OpinionPhysicians argue a positionInterviewsConversations with the people shaping the fieldDebatesTwo physicians, one questionFrom the EditorsNotes from the longevitydocs™ editors
What People Get Wrong About Longevity Medicine
By David Luu, MD