Therapeutics
What physicians prescribe, and what the evidence supports.
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Free, delivered by Substack. Unsubscribe any time.RESEARCH
New StudiesWhat was published and what it meansClinical TrialsWhat is enrolling, what is reading outEvidence CheckWhere the data stands on a claimResearch TranslationFrom the lab to the clinicBiology of AgingHallmarks, senescence, epigenetics
Caloric restriction improves a composite aging-biomarker index
By longevitydocs™ editors
Menopause leaves a molecular signature linked to brain aging
By longevitydocs™ editorsCLINICAL PRACTICE
Practice ModelsHow longevity care is structured and deliveredClinical CasesReal patients, real clinical decisionsGuidelines & StandardsConsensus statements and best practiceField ReportsCLDs on what works in their practice
Ferritin below 30 is the new line
By longevitydocs™ editors
Where can I find a longevity doctor?
By David Luu, MDTHERAPEUTICS
Metabolic HealthGLP-1s, insulin, cardiometabolic riskHormones & Midlife CareHRT, testosterone, menopauseSupplements & PeptidesWhat is proven, what is notRegenerative MedicineStem cells, exosomes, PRPSkin & Aesthetic LongevityLongevity dermatology and aesthetics
Tirzepatide earns its first outcomes label
By longevitydocs™ editors
The Lp(a) drug moved the number, not the outcome
By longevitydocs™ editorsDIAGNOSTICS
BiomarkersBlood panels, ApoB, inflammationBiological AgeEpigenetic clocks and how to read themImagingFull-body MRI, CAC scores, DEXAGenomicsPolygenic risk, pharmacogenomicsScreening & PreventionEarly detection and risk reduction
Alzheimer’s blood tests are for symptomatic patients, not screening
By longevitydocs™ editors
Which longevity data is worth acting on?
By David Luu, MDTECHNOLOGY
AI in MedicineClinical tools, decision supportWearables & Remote MonitoringCGMs, rings, continuous dataDevices & At-Home CareHome diagnostics and hardwareDigital Health InfrastructurePlatforms, records, telehealth
Lab-grade breath testing goes self-serve
By longevitydocs™ editors
Your ring now carries your chart
By longevitydocs™ editorsBUSINESS
Clinics & PracticesModels, pricing, operationsCare DeliveryHow providers and health systems offer longevity carePharma & BiotechPipelines, launches, trialsDeals & FundingRaises, M&A, partnerships
System raises $20M to own the peptide supply chain
By longevitydocs™ editors
Bryan Johnson’s Immortals Concierge: from $75k to $1M
By longevitydocs™ editorsPOLICY
Regulation & EnforcementFDA actions, compounding, warningsPayment & ReimbursementCoverage, codes, payersLicensure & StandardsScope of practice, credentialingGlobal PolicyHow other countries regulate longevity care
FDA puts a major GLP-1 compounder on notice
By longevitydocs™ editors
$16.4 trillion: the economic case for prevention
By longevitydocs™ editorsVOICES
OpinionPhysicians argue a positionInterviewsConversations with the people shaping the fieldDebatesTwo physicians, one questionFrom the EditorsNotes from the longevitydocs™ editors
What People Get Wrong About Longevity Medicine
By David Luu, MD