Research
New studies and what they mean for practice, read by physicians.
Caloric restriction improves a composite aging-biomarker index
Across 7 pooled RCTs (829 older adults), caloric restriction improved a six-marker index modeled on the TAME trial (CRP, IL-6, cystatin C, insulin, GDF-15 and TNF-R1).
Menopause leaves a molecular signature linked to brain aging
Blood proteomics identified a 16-protein inflammatory, synaptic and Alzheimer’s-related signature (including CCL2, BACE1 and p-tau231).
Regular exercise rewires immune cells at the chromatin level
We know exercise protects against metabolic disease and infection. This paper asks what it does to the blood.
REM sleep tracks lower risk across 83 diseases in 95,559 UK Biobank adults
Nearly 96,000 UK adults wore a wrist tracker for a week, and researchers followed their health records for about nine years, checking against more than a thousand diagnoses.
Ask about the parents. It beats the polygenic score.
1,126 Swedish 70-year-olds, followed six years. Having two parents who lived past 85 tracked with less hypertension, higher MMSE, lower BMI, lower homocysteine, lower IL-6 and CRP, less smoking, and a slower rise in plasma pTau217.
An AI-designed drug moved six aging clocks. In IPF patients. For 12 weeks.
Proteomic substudy of the Phase 2a IPF trial of rentosertib, Insilico’s TNIK inhibitor (n=42).
Aging-related disease is now the largest burden a newborn will face
Using Global Burden of Disease data, the authors sort every disease into four life-stage clusters: infant, early adult, later adult, and ageing-related.
Launching the First Longevity Clinical Trial Network
Longevity medicine is emerging fast. Yet as the field grows, so does the need for validation. Today, most interventions are supported by small studies, animal data, or anecdotal success.
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