Which longevity data is worth acting on?
For years, we said we didn’t have enough data for precision medicine. Now we have more than we can interpret.
FDA puts a major GLP-1 compounder on notice
Clinical Practice · Practice ModelsWhere can I find a longevity doctor?
Technology · Digital Health InfrastructureCan your phone become a longevity clinic?
Clinical Practice · Practice ModelsHow to Design a Patient Journey for a Longevity Clinic
Caloric restriction improves a composite aging-biomarker index
Across 7 pooled RCTs (829 older adults), caloric restriction improved a six-marker index modeled on the TAME trial (CRP, IL-6, cystatin C, insulin, GDF-15 and TNF-R1).
DiagnosticsMulti-cancer blood test performance in 35,900 adults (PATHFINDER 2)
PATHFINDER 2 evaluated the Galleri multicancer detection test in adults aged 50 and older.
ResearchMenopause leaves a molecular signature linked to brain aging
Blood proteomics identified a 16-protein inflammatory, synaptic and Alzheimer’s-related signature (including CCL2, BACE1 and p-tau231).
Latest
The Sunday edition.
The week in longevity medicine, every Sunday.
Free, delivered by Substack. Unsubscribe any time.Research
New studies and what they mean for practice, read by physicians.
Clinical Practice
How longevity medicine is delivered: practice models, cases and standards.
Ferritin below 30 is the new line
The 2026 American Society of Hematology guidelines in Blood Advances keep ferritin as the best first test. They move the adult low cutoff from below 15 to below 30.
Where can I find a longevity doctor?
We hear this question more every week. From patients: “Who is the best in New York?” From colleagues: “Do you know someone who works on hormones and longevity?” From a friend: “I need a cardiologist who goes deeper than the guideline.”
How to Design a Patient Journey for a Longevity Clinic
Three weeks ago this series started with why doctors are making the move. Then 26 physicians said what not to do. Last week, the systems. This week, the patient’s year, on one page.
Is Your Clinic Longevity-Ready?
Longevity medicine should be more than a menu of tests and therapies. It should be physician-led, grounded in evidence, transparent about uncertainty, measured by outcomes, and supported by systems that protect patients and clinical judgment.
Therapeutics
What physicians prescribe, and what the evidence supports.
Tirzepatide earns its first outcomes label
FDA approved tirzepatide to reduce MACE in adults with type 2 diabetes at cardiovascular risk. The claim rests on SURPASS-CVOT against dulaglutide, an active comparator, with an 8% relative reduction.
The Lp(a) drug moved the number, not the outcome
Novartis and Ionis reported topline Phase III results from Lp(a)HORIZON on September 4: 8,323 patients with elevated Lp(a) and established cardiovascular disease on guideline-directed therapy.
Diagnostics
Biomarkers, imaging and the tests entering the longevity visit.
Alzheimer’s blood tests are for symptomatic patients, not screening
Four Alzheimer's blood tests now have FDA clearance, including PrecivityAD2 and Roche's Elecsys pTau217.
Which longevity data is worth acting on?
For years, we said we didn’t have enough data for precision medicine. Now we have more than we can interpret.
Multi-cancer blood test performance in 35,900 adults (PATHFINDER 2)
PATHFINDER 2 evaluated the Galleri multicancer detection test in adults aged 50 and older.
Aging Rate Indicators (ARI) measure pace, not accumulated age
A biological-age clock is an odometer: how far you have aged. An aging rate indicator, or ARI, would be a speedometer: how fast you are aging now.
Technology
AI, wearables and the tools entering the exam room.
Lab-grade breath testing goes self-serve
PNOĒ's new mask runs an 8-minute breath test that claims to measure 23 metabolic markers, including a VO2-style fitness reading.
Your ring now carries your chart
Ultrahuman's new HealthEx add-on lets US ring users pull their medical records through TEFCA, the national health-data exchange.
Can your phone become a longevity clinic?
iOS 27 ships tomorrow. A Longevity tab, a Health Age built from VO2 max, resting heart rate, HRV, sleep and blood work, and a Quest panel of 50+ biomarkers ordered inside the app for $119.
A hormone panel from behind the ear, n=12
Phira unveiled a behind-ear wearable that models estrogen, LH, and progesterone dynamics from skin temperature at 0.03°C resolution, not from blood or urine.
Business
Companies, capital and care delivery shaping longevity medicine.
System raises $20M to own the peptide supply chain
System raised $20M to run the full chain: patient, US-licensed clinician, certified compounding pharmacy, front door.
Bryan Johnson’s Immortals Concierge: from $75k to $1M
Fully managed care from Johnson's medical team. Dedicated physician, coach, coordinator, full-body MRI, coronary CT, multi-cancer early detection, DEXA, 200+ biomarkers, epigenetic workups, Whoop and Oura, Blueprint supplements.
Policy
Regulation, payment and the standards that govern longevity care.
Voices
Opinion and perspective from physicians in the longevitydocs™ network.
What People Get Wrong About Longevity Medicine
I have spent this year in a lot of different countries, different cities, different rooms. Same questions every time.
10 learnings from longevitydocs Cannes 2026
We started the way the Murphys started: by showing up and inviting everyone to the table. The White Party on the deck of the Majestic, mocktails on the water, then dinner at the Palm Beach. Everyone in white.
Launching Jobs: refer, hire, partner
Every day we get demands for a new medical director, or a physician asking to refer a patient to another specialist. Hiring. Referrals. Partners. So we built Jobs.
Once upon a time in Cannes
In 1959, my father landed in Cannes. He became a physician and participated in the creation of the first university diploma in acupuncture at the University of Montpellier.
