The study
Across 7 pooled RCTs (829 older adults), caloric restriction improved a six-marker index modeled on the TAME trial (CRP, IL-6, cystatin C, insulin, GDF-15 and TNF-R1). About half the effect came from weight loss, and some signal remained independent of weight.
What it means for practice
that gives geroscience a practical, repeatable readout of aging biology, and a way to compare interventions head to head in clinic and in trials. The next step is linking the index to function and clinical events.
Source: Guida, Hsu, Neiberg et al. | GeroScience | Sep 12, 2026
Originally published in The Longevity Medicine Intelligence newsletter (#108).
WRITTEN BYlongevitydocs™ editorsCurated by the longevitydocs™ editorial team from the weekly newsletter
