Latest
Everything we have published, newest first.
FDA puts a major GLP-1 compounder on notice
In a September 18 warning letter, FDA said Empower Pharmacy appeared to compound semaglutide and tirzepatide products that were essentially copies of approved drugs in substantial quantities.
Lab-grade breath testing goes self-serve
PNOĒ's new mask runs an 8-minute breath test that claims to measure 23 metabolic markers, including a VO2-style fitness reading.
Alzheimer’s blood tests are for symptomatic patients, not screening
Four Alzheimer's blood tests now have FDA clearance, including PrecivityAD2 and Roche's Elecsys pTau217.
$16.4 trillion: the economic case for prevention
A McKinsey Health Institute and Abu Dhabi Future Health whitepaper models an upper-bound scenario in which eliminating modifiable behavioral, metabolic, and environmental risks could add $16.4 trillion to annual global GDP in 2050.
Your ring now carries your chart
Ultrahuman's new HealthEx add-on lets US ring users pull their medical records through TEFCA, the national health-data exchange.
Which longevity data is worth acting on?
For years, we said we didn’t have enough data for precision medicine. Now we have more than we can interpret.
Caloric restriction improves a composite aging-biomarker index
Across 7 pooled RCTs (829 older adults), caloric restriction improved a six-marker index modeled on the TAME trial (CRP, IL-6, cystatin C, insulin, GDF-15 and TNF-R1).
Multi-cancer blood test performance in 35,900 adults (PATHFINDER 2)
PATHFINDER 2 evaluated the Galleri multicancer detection test in adults aged 50 and older.
Menopause leaves a molecular signature linked to brain aging
Blood proteomics identified a 16-protein inflammatory, synaptic and Alzheimer’s-related signature (including CCL2, BACE1 and p-tau231).
Deepfake doctors are selling pills
CBC reports that AI-generated ads using the faces and voices of prominent Canadian physicians are circulating on Facebook and TikTok, selling prostate treatments, joint pills and “$1 million satisfaction guarantees.” Dr.
Bill Targets Corporate Control of Doctors
The Stop Corporate Takeovers of Physicians Act, introduced Sept 16 by Senators Warren, Wyden and Merkley, would bar private equity, insurers and other non-physician-controlled businesses from owning or directing medical practices.
FDA opens the file on testosterone for menopause
On Sept 17, FDA’s Office of Women’s Health and Center for Drug Evaluation and Research (CDER) held a public workshop on testosterone use in menopausal women: benefits, dosing, lab interpretation and long-term safety, with the stated aim of informing research and drug development.
Ferritin below 30 is the new line
The 2026 American Society of Hematology guidelines in Blood Advances keep ferritin as the best first test. They move the adult low cutoff from below 15 to below 30.
Where can I find a longevity doctor?
We hear this question more every week. From patients: “Who is the best in New York?” From colleagues: “Do you know someone who works on hormones and longevity?” From a friend: “I need a cardiologist who goes deeper than the guideline.”
Regular exercise rewires immune cells at the chromatin level
We know exercise protects against metabolic disease and infection. This paper asks what it does to the blood.
REM sleep tracks lower risk across 83 diseases in 95,559 UK Biobank adults
Nearly 96,000 UK adults wore a wrist tracker for a week, and researchers followed their health records for about nine years, checking against more than a thousand diagnoses.
Aging Rate Indicators (ARI) measure pace, not accumulated age
A biological-age clock is an odometer: how far you have aged. An aging rate indicator, or ARI, would be a speedometer: how fast you are aging now.
System raises $20M to own the peptide supply chain
System raised $20M to run the full chain: patient, US-licensed clinician, certified compounding pharmacy, front door.
Can your phone become a longevity clinic?
iOS 27 ships tomorrow. A Longevity tab, a Health Age built from VO2 max, resting heart rate, HRV, sleep and blood work, and a Quest panel of 50+ biomarkers ordered inside the app for $119.
Bryan Johnson’s Immortals Concierge: from $75k to $1M
Fully managed care from Johnson's medical team. Dedicated physician, coach, coordinator, full-body MRI, coronary CT, multi-cancer early detection, DEXA, 200+ biomarkers, epigenetic workups, Whoop and Oura, Blueprint supplements.
Ask about the parents. It beats the polygenic score.
1,126 Swedish 70-year-olds, followed six years. Having two parents who lived past 85 tracked with less hypertension, higher MMSE, lower BMI, lower homocysteine, lower IL-6 and CRP, less smoking, and a slower rise in plasma pTau217.
An AI-designed drug moved six aging clocks. In IPF patients. For 12 weeks.
Proteomic substudy of the Phase 2a IPF trial of rentosertib, Insilico’s TNIK inhibitor (n=42).
How to Design a Patient Journey for a Longevity Clinic
Three weeks ago this series started with why doctors are making the move. Then 26 physicians said what not to do. Last week, the systems. This week, the patient’s year, on one page.
A hormone panel from behind the ear, n=12
Phira unveiled a behind-ear wearable that models estrogen, LH, and progesterone dynamics from skin temperature at 0.03°C resolution, not from blood or urine.
Oura is going public with 3.6 million people's worth of data
Oura filed for a US listing with roughly $1.21B in revenue over nine months and more than 3.6M rings sold in the past year.
Tirzepatide earns its first outcomes label
FDA approved tirzepatide to reduce MACE in adults with type 2 diabetes at cardiovascular risk. The claim rests on SURPASS-CVOT against dulaglutide, an active comparator, with an 8% relative reduction.
The Lp(a) drug moved the number, not the outcome
Novartis and Ionis reported topline Phase III results from Lp(a)HORIZON on September 4: 8,323 patients with elevated Lp(a) and established cardiovascular disease on guideline-directed therapy.
ChatGPT is now reading your Epic chart
ChatGPT for Healthcare integrates with Epic. Authorized physicians can pull labs, medications, notes, and specialist documentation into ChatGPT, or use it embedded in Epic, with UCSF Health as the named pilot.
Aging-related disease is now the largest burden a newborn will face
Using Global Burden of Disease data, the authors sort every disease into four life-stage clusters: infant, early adult, later adult, and ageing-related.
Semaglutide, started late, extended life in mice
Female mice started daily semaglutide at 20 months, roughly a human mid-60s, and stayed on it for life. Median lifespan rose from 742 to 834 days, about 12%.
Is Your Clinic Longevity-Ready?
Longevity medicine should be more than a menu of tests and therapies. It should be physician-led, grounded in evidence, transparent about uncertainty, measured by outcomes, and supported by systems that protect patients and clinical judgment.
Mistakes to Avoid When Building a Longevity Practice
Longevity medicine has a growing clinical literature and no operational one. Physicians opening practices have no published standards, no pricing benchmarks, no model comparisons, no software evaluations, and no account of what the first eighteen months actually cost.
Why More Doctors Are Moving Into Longevity Medicine
Issue 102. I started watching Best Medicine on Netflix yesterday - don’t judge please. A heart surgeon leaves Boston for a village practice. He was used to treating the organ, fixing the patient, next.
What People Get Wrong About Longevity Medicine
I have spent this year in a lot of different countries, different cities, different rooms. Same questions every time.
FDA advisory committee recommends six peptides for compounding
The question at hand was never whether these compounds should be FDA approved. It was whether a licensed 503A compounding pharmacy should be legally permitted to prepare them for an individual patient holding a valid prescription from a licensed clinician.
Inside Shanghai and Seoul's top longevity clinics
I just spent two weeks in Shanghai and Seoul, meeting physicians and leaders and walking through their clinics and hospitals. Here is my honest summary, the opportunities and the challenges:
The Longevity Tourism Boom
Longevity spa, longevity retreats, or longevity checkup. Longevity is everywhere. A hotel in the Swiss Alps is selling a “longevity suite” with cryotherapy and IV drips.
10 learnings from longevitydocs Cannes 2026
We started the way the Murphys started: by showing up and inviting everyone to the table. The White Party on the deck of the Majestic, mocktails on the water, then dinner at the Palm Beach. Everyone in white.
What's a Longevity Doctor? 10 Traits
When I started medical school, I wanted to save lives. Surgery, transplants, the adrenaline of the ER. I trained to treat disease. But by the time I saw most patients, the damage was already done.
Acquire Patients Better: The Physician-Patient Fit Checklist
In startups, nothing happens until you find product-market fit. In longevity medicine, nothing happens until you find patient-physician fit (PPF).
How to build a $1M longevity clinic
You are starting you longevity clinic or want to grow it. Like any business, you need a revenue target. I am using $1M because it is the number where investors start paying attention.
Launching Jobs: refer, hire, partner
Every day we get demands for a new medical director, or a physician asking to refer a patient to another specialist. Hiring. Referrals. Partners. So we built Jobs.
The longevitydocs mobile app is live
News. Curated longevity medicine intelligence, daily. New research, business moves, regulatory shifts. Two minutes. You’re current.
Once upon a time in Cannes
In 1959, my father landed in Cannes. He became a physician and participated in the creation of the first university diploma in acupuncture at the University of Montpellier.
We are launching Events
Peer learning has always been a medical tradition. The conference was just the easiest format. There is no community without programming. A once-a-year gathering is not enough.
Rooms: the digital lounge for longevity doctors
There used to be a place where doctors talked to each other. Not in a chat thread. Not on a podcast. In a room.
Should Doctors Build a Personal Brand?
This cover story started in our chat. One doctor shared the social media agency he uses. Full production. Other docs chimed in. Some impressed. Some skeptical. Most asking the same thing quietly: should I be doing this too?
Launching longevitydocs 2.0
In February, we asked you a simple question: what do you actually need? The answers were clear: a searchable forum, shared protocols, a resource library, direct messaging between members. Not a WhatsApp group. A real home.
The Longevity Clinic Gold Rush
In 2020, longevity clinics were a niche experiment. In 2026, they are a global industry. Serotonin Centers crossed 100 franchise locations inside gyms. Next Health sold 50+ territories. Fountain Life raised $108M.
Ambient Longevity Already Exists.
What if the data needed to guide you toward a longer, healthier, happier life already existed… and nobody was using it?
The Longevity Care Battle: Physician vs Digital Platform
The battle for longevity medicine has begun. On one side: digital platforms armed with venture capital, AI tools, and frictionless patient acquisition.
Welcome to Hippo: AI learning Assistant for longevity medicine
This morning I opened Hippo and asked it to create a Quiz session. Within minutes I'd tested my knowledge, found a gap I didn't know I had, and moved on with my newsletter. A quick, focused way to build longevity fluency.
From Barber To Longevity Doctor
As physicians, we’ve spent decades mastering our craft. Now, technology is reshaping everything we thought we knew about how medicine works.
The longevity clinic tech stack
Technology is moving faster than medicine’s infrastructure can support it. The FDA just exempted AI health tools from oversight. Tech companies are building ‘body-scan’ centers.
The AI Doctor Is Born
The AI doctor didn’t arrive with a white coat or a press conference. It arrived quietly, and soon it will be everywhere.
2026 - The Longevity Medicine Manifesto
Not wellness theater. Not optimization trends. Not biohacking content for social media. Real medicine: practiced by physicians, grounded in evidence, accountable to standards, impacting patient’s lives.
2025 Longevity Medicine Recap: What Accelerated, What Broke
When we started building in 2021, most people were still asking: “What is longevity medicine, exactly?” 2025 was the year longevity medicine escaped the clinic and entered society. Here’s what actually happened.
How to become a Longevity Doctor
This week, I was in rooms with physicians who believe deeply in the future of longevity medicine. What I heard wasn’t about hype or protocols, they are asking for standards to help them:
Longevity Tour: 50 Lessons from 5 Cities
1. Longevity medicine mirrors emergency medicine in the 1970s: early, undefined, debated but inevitable. 2. Three years ago these conversations were speculative. Today they are clinical, technical, and operational. 3.
Introducing longevitydocs.network
The longevity space is accelerating fast. Biomarkers, wearables, and AI are everywhere. But every company I speak with hits the same wall:
The Biomarker Gold Rush
Function Health raised $298M, dropped membership to $365/year, and launched Medical Intelligence Lab: an AI engine merging 160+ biomarkers, full-body imaging, wearables, and medical records into personalized protocols.
10 core challenges longevity doctors are facing right now
Last week, I met with 25 physicians passionate about evidence-based longevity medicine. What I heard wasn’t about the promising interventions, it was about the reality of building a new field from scratch.
Launching the First Longevity Clinical Trial Network
Longevity medicine is emerging fast. Yet as the field grows, so does the need for validation. Today, most interventions are supported by small studies, animal data, or anecdotal success.
Doctor-Led Longevity: The New Standard of Care
Why physicians will define the next frontier of preventive medicine and make longevity accessible to everyone.
The rise of TikTok medicine
A few years ago, we were worried about “Doctor Google.” Now we have “TikTok Docs” Medicine didn’t disappear with, newspapers, blogs or tweets, and it won’t disappear with reels.
The longevity EMR of the future
We all feel it. The system just doesn’t work. So I decided to write about what should. I feel you, doctors. I’ve been there too. We’ve all tried them, and yet no platform truly fits how we practice longevity medicine.
What is longevity medicine? From origins to futurism
The desire to live longer and better is as old as humanity itself. From the Epic of Gilgamesh to the Taoist search for immortality and the Greek idea of bios kalos, meaning “the good life,” every civilization has sought to stretch time.
Inside the longevitydocs Peptide Mastermind
If you walked into that room, you could feel it, the curiosity, the energy, the collective intelligence. From biology to regulation, the debate was intense, deeply respectful, and often humbling.
Virtual Mastermind: live and recorded access is back
We heard you. After so many requests from physicians around the world, we’ve decided to bring back virtual live tickets + recordings for our upcoming Peptides Mastermind.
Smart investments for physicians
This Friday, our Private Club dives into a question every physician-builder faces: how to invest wisely and strategically in longevity medicine.
Certification Cohort 3 is open
We’re opening Cohort 3 of the Certified Longevity Physician™: for practicing MDs who want evidence, outcomes, and an elite peer circle.
longevitydocs Tables launch in the US
After traveling and meeting so many of you this year, one thing became clear: We need more space to connect, share, and learn from each other.
Longevity on a budget: the 50-cents-a-day promise
A VC-backed startup has launched a $199-per-year membership that promises to detect “over 1,000+ preventable conditions” through annual lab testing.
longevitydocs Concierge
Finding a trusted longevity doctor is harder than it should be. Many people waste time searching online, bouncing between clinics, and wondering if they’re really getting the best care. It’s overwhelming, and often discouraging.
Peptides: meet the doctors speaking at the Mastermind
That’s why we’re bringing together the physicians who study, research, prescribe, and teach about peptides, so you can learn directly from the best how peptides can transform your practice, improve patient outcomes, and keep you at the forefront of modern medicine.
Readers in 100+ countries: why this matters
From physicians in Mumbai and Melbourne to entrepreneurs in Berlin and investors in São Paulo… we’re proving something powerful:
